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Study population is quite diverse as affected participants are from all over the world. Is willing to allow storage of biological specimens for future use in medical research. Is willing to allow genetic testing on collected biological samples.

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Is willing to allow genetic testing on collected biological samples.

Participants must meet one of the following criteria: Clinical characteristics strongly consistent with an undifferentiated autoinflammatory disease. Participants must meet both of the following criteria: Clinical char strongly consistent with an IL-1 mediated autoinflammatory disease per the following criteria and at the discretion of the principal investigator PI. Individuals must have a past or present history of one of the clinical and one of the laboratory characteristics mentioned above to be considered for study enrollment.

Not be related to an affected participant.

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Has a primary care or other physician who will manage all health conditions related or unrelated to the study objectives. Is willing to allow storage of biological specimens for future use in medical research.

Has clinical s or symptoms not explained by any other disorder eg, infections, malignancies and are consistent with a possible IL-1 mediated autoinflammatory disease. Be related by blood to an affected participant.

Does not fulfill any of inclusion criterion 5 for affected participants. These patients will not be excluded from the study.

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Individuals must have a past or present history of one of the following to be considered for study enrollment: Recurrent fevers that has gone undiagnosed after reasonable attempts, and that is consistent with the conditions under study in this protocol Panniculitis, ischemic ulcerative skin lesions, chilblain lesions, or livedo reticularis Lipodystrophy Myositis, arthralgias, arthritis, or t contractures Basal ganglia calcifications or white matter CNS disease Interstitial lung disease, lung fibrosis, or pulmonary hypertension Conjunctivitis, episcleritis, cortical blindness, glaucoma, papilledema, or hepatosplenomegaly Laboratory characteristics strongly consistent with an IFN-mediated autoinflammatory disease per the following criteria.

Has clinical s or symptoms not explained by any other disorder eg, infections, malignancies and are consistent with a possible IFN-mediated, autoinflammatory disease.

Individuals must have past or present history one or more of the following to be considered for study enrollment: Zolotgorskiy of systemic inflammation eg, ESR or CRP Cytopenias eg. Individuals with defined organ inflammation associated with past or current evidence of systemic inflammation.

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Please refer to this study by its ClinicalTrials. Study population is quite diverse as affected participants are from all over the world.

Is willing to allow storage of biological samples for future use in medical research. Oncological evaluation suggestive of lymphoma, leukemia or multiple myeloma, except for participants with a known primary diagnosis of an autoinflammatory disease who subsequently developed a malignancy.